Virtual Workshop (1day)- Lineage infidelity and cell of origin of hematologic malignancies
Lineage infidelity in acute leukemia is defined by cross-lineage marker expression such as B- and/or T-lymphoid antigen expression on myeloid blasts or vice versa. Lineage plasticity denotes a process by which leukemic cells change from one morphological, immunophenotypic and functional cell type to another (and back), under the influence of particular environmental/therapeutic pressures. Both lineage infidelity and plasticity have been proposed as a potential mechanism of therapeutic resistance. Although the pathogenesis remains to be studied, cell-of-origin may underscore the biology of both phenomena. This workshop brings together basic, translational, and clinical researchers to discuss and debate these biological processes. Taken together, participants at this workshop will gain new insight into the biology of lineage infidelity, lineage plasticity and cell of origin, as well as have opportunities to cultivate new ideas and establish collaborations with researchers from disparate disciplines.
1. To bridge the gap between basic and clinical research
2. To explore the pathogenesis of lineage infidelity/plasticity
Omar Abdel-Wahab, MD, Center for Hematologic Malignancies, HOPP
Ahmet Dogan, MD, PhD, Department of Pathology and Laboratory Medicine
Ross Levine, MD, HOPP, Center for Hematologic Malignancies
Wenbin Xiao, MD, PhD, Department of Pathology and Laboratory Medicine